Drug intelligence / Profile preview

vernonia amygdalina

Development stage
Preclinical
Administration
Oral, Topical
01

Overview

Vernonia amygdalina is a perennial shrub or small tree belonging to the Asteraceae family, commonly known as bitter leaf due to its bitter taste. It grows in most parts of sub-Saharan Africa, particularly in tropical regions. The plant reaches heights of 2-5 meters with elliptical green leaves up to 20cm long. The leaves, stems, and bark contain various bioactive compounds including flavonoids, alkaloids, saponins, tannins, triterpenoids, sesquiterpene lactones, steroids, cardiac glycosides, and phenols. These compounds contribute to its numerous medicinal properties. Vernonia amygdalina has demonstrated multiple pharmacological activities including: - Anti-inflammatory and analgesic effects - Antioxidant properties - Antimalarial activity - Antidiabetic effects - Antibacterial and antifungal properties - Antiparasitic/anthelmintic activity - Anticancer potential Traditionally, it has been used for treating various conditions including fever, malaria, diabetes, gastrointestinal disorders, kidney problems, and as a fertility inducer in subfertile women.

Other names
Bitter LeafEwuroOnugbuOriwoItyunaGrawa
02

Targets

KRAS (Kirsten rat sarcoma viral oncogene homolog)SRC (Proto-oncogene tyrosine-protein kinase Src)

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