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YF135
- Development stage
- Unknown
- Lead developer
- Jinan University
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
01
Overview
YF135: sourced facts only. name: "Herein, we report the development of YF135, the first reversible-covalent PROTAC capable of recruiting VHL mediated proteasomal degradation of KRASG12C." [PMID:35007863]; target: "Herein, we report the development of YF135, the first reversible-covalent PROTAC capable of recruiting VHL mediated proteasomal degradation of KRASG12C." [PMID:35007863]; developer: "College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, 510632, China." [PMID:35007863]; modality: "Herein, we report the development of YF135, the first reversible-covalent PROTAC capable of recruiting VHL mediated proteasomal degradation of KRASG12C." [PMID:35007863]; stage: "YF135 induces the rapid and sustained degradation of endogenous KRASG12C and attenuates pERK signaling in H358 and H23 cells in a reversible manner." [PMID:35007863]
02
Targets
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