Drug intelligence / Profile preview

Yishen Granule

Development stage
Preclinical
Lead developer
Guangzhou Kangchen Pharmaceutical
Administration
Oral
01

Overview

**Yishen Granule** is an orally administered, hospital-prepared traditional Chinese multi-herb formula used in clinical research in Shanghai. Reported ingredients are lingzhi, prepared *Polygonum multiflorum*, *Polygonatum* rhizome, honey-fried astragalus, and stir-fried angelica. Its molecular mechanism has not been established as a defined target-based pharmacologic action. A randomized controlled trial evaluated Yishen Granule, alone and with acupuncture, in older adults with mild cognitive impairment; a separate registered study and clinical report evaluated it for chemotherapy-induced myelosuppression in patients with lung cancer. ([pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC6371495/))

Other names
YSG益神颗粒
02

Targets

JAK2 (Janus kinase 2)STAT3 (Signal Transducer and Activator of Transcription 3)TGFB (GARP–latent transforming growth factor beta 1 complex)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)HIF1A (Hypoxia-inducible factor 1-alpha)TP53 (Cellular Tumor Antigen p53 R175H)AR (Adrenergic receptors)

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