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ZBEAM
- Development stage
- Unknown
- Lead developer
- IDEC
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Oral, Subcutaneous, Intrathecal, Intra-arterial, Implant
01
Overview
ZBEAM is a combination chemotherapy and radioimmunotherapy regimen primarily utilized in the treatment of high-grade B-cell lymphoma, often as a preparative regimen before autologous stem cell transplantation. The regimen combines Yttrium-90 Ibritumomab Tiuxetan (Zevalin), a radioimmunoconjugate, with the BEAM chemotherapy regimen. The BEAM component consists of four cytotoxic agents: Carmustine, Etoposide, Cytarabine, and Melphalan. This multi-modal approach leverages targeted radiation, DNA alkylation, topoisomerase inhibition, and antimetabolite action to induce significant cytotoxicity in malignant B-cells.
- Other names
- Zevalin-BEAMZevalin + BEAMYttrium-90 ibritumomab tiuxetan plus BEAMYttrium90 ibritumomab tiuxetan plus BEAMYttrium 90 ibritumomab tiuxetan plus BEAM
02
Targets
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