ZM-39923

ZM-39923 is a small molecule experimental drug primarily known as a potent and selective inhibitor of Janus kinase 3 (JAK3), with additional inhibitory activity against JAK1, epidermal growth factor receptor (EGFR), cyclin-dependent kinase 4 (CDK4), and tissue transglutaminase (TGM2)[6][5][7]. It acts as a prodrug that breaks down in neutral buffer to form the active JAK3 inhibitor ZM449829[4][8]. The compound has been used extensively in research settings to study JAK/STAT signaling pathways and transglutaminase biology. It is not approved for clinical use and remains investigational[2]. In addition to its kinase inhibition profile, it has shown effects in disease models such as Machado-Joseph Disease in Drosophila melanogaster[4].

Other names

1-propanone, 3-((1-methylethyl)(phenylmethyl)amino)-1-(2-naphthalenyl)-3-(benzyl(propan-2-yl)amino)-1-(naphthalen-2-yl)propan-1-oneJak3 inhibitor ivJak-3 inhibitor ivJak 3 inhibitor iv