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Target intelligence / Profile preview
Cancer Cell Membrane Proteins
- Molecular classification
- Receptor Tyrosine Kinase, G-protein Coupled Receptor, Integrin, Transporter, ABC Transporter, Cell Adhesion Molecule, Enzyme, Antigen
01
Overview
Cancer cell membrane proteins are a diverse group of proteins expressed on the surface of cancer cells. They play critical roles in various aspects of cancer biology, including signal transduction, cell adhesion, migration, nutrient transport, drug resistance, and immune evasion. Their accessibility makes them attractive therapeutic targets and biomarkers for cancer diagnosis and prognosis.
- Other names
- Tumor cell surface proteinsCancer-associated membrane proteinsPlasma membrane proteins in cancer
02
Mechanism of action
Inhibition of receptor signaling, blocking cell adhesion, blocking nutrient transport, inducing antibody-dependent cell-mediated cytotoxicity (ADCC)
03
Biological functions
Signal transductionCell adhesionCell migrationNutrient transportDrug effluxImmune evasionCell-cell interactionsECM interaction
04
Disease associations
CancerTumor growthMetastasisDrug resistance
05
Safety considerations
Off-target effects of inhibitorsDevelopment of resistance to targeted therapiesImmune-related adverse eventsTumor heterogeneity
06
Interacting drugs
2 more in the full profile.
07
Biomarkers
EGFR expressionHER2/ErbB2 expressionIntegrin expression levelsGLUT1 expressionABCB1/P-gp expression
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