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Target intelligence / Profile preview
Carbonic anhydrase 9 (CA9)
- Target
- CA9
- Molecular classification
- Enzyme, Zinc metalloenzyme, Transmembrane protein
01
Overview
Carbonic anhydrase 9 (CA9) is a transmembrane zinc metalloenzyme that catalyzes the reversible hydration of carbon dioxide. It plays a crucial role in regulating pH, particularly in hypoxic tumor microenvironments. CA9's unique structural features and expression pattern make it a promising therapeutic target for cancer treatment.
- Other names
- Carbonic anhydrase IXCA IX
02
Mechanism of action
Inhibition of CA9 enzymatic activity, disruption of CA9 dimerization, or antibody-mediated targeting of CA9 on tumor cells.
03
Biological functions
Catalysis of CO₂ hydration/dehydrationRegulation of intracellular pHRegulation of extracellular pHCell adhesionSignal transduction
04
Disease associations
Cancer
05
Safety considerations
Potential off-target effects on other carbonic anhydrase isoformsLimited expression in normal tissues may not prevent all off-target effects
06
Biomarkers
Tumor hypoxiaPrognostic indicator in cancer
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