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DNA Topoisomerase II Beta (TOP2B)
- Target
- TOP2B
- Molecular classification
- Enzyme, DNA Topoisomerase, Type II Topoisomerase
01
Overview
DNA Topoisomerase II Beta (TOP2B) is a type II topoisomerase enzyme essential for managing DNA topology during transcription, replication, chromosome condensation, and chromatid separation. It introduces transient double-stranded breaks in DNA to relieve torsional stress and resolve catenanes. TOP2B is a target for anticancer agents, but mutations can lead to drug resistance and other disease states.
- Other names
- Topoisomerase (DNA) II BetaDNA topoisomerase 2-betaTop2b
02
Mechanism of action
Drugs targeting TOP2B, such as mitoxantrone, induce double-strand breaks in DNA by interfering with the enzyme's ability to religate the DNA after strand passage.
03
Biological functions
DNA topology managementTranscription regulationReplicationChromosome condensationChromatid separationRelieving torsional stress
04
Disease associations
CancerImmunodeficiencyNeurological disorders (e.g., autism)Drug resistanceAtaxia-telangiectasia (possible)
05
Safety considerations
Drug resistanceInduction of secondary malignanciesCardiotoxicity (for some TOP2B inhibitors)
06
Interacting drugs
Mitoxantrone
2 more in the full profile.
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