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Target intelligence / Profile preview
Epidermal Growth Factor Receptor 2 (HER2)
- Target
- HER2
- Molecular classification
- Receptor, Receptor Tyrosine Kinase, Transmembrane Receptor
01
Overview
HER2 is a membrane-bound receptor tyrosine kinase that lacks direct ligand binding but becomes activated through dimer formation. Its overexpression drives aggressive tumor behavior—most notably in breast cancer—and has become central both diagnostically and therapeutically within oncology practice today.
- Other names
- ERBB2CD340Neu
02
Mechanism of action
Targeted therapies against HER2 inhibit its signaling, leading to reduced cell proliferation and survival in HER2-positive cancers.
03
Biological functions
Cell proliferationCell survivalCell differentiationAngiogenesisInvasionMetastasisSignal transduction
04
Disease associations
Cancer
05
Safety considerations
CardiotoxicityResistance to targeted therapiesLess favorable outcomes in tumor types other than breast/gastric cancers
06
Interacting drugs
07
Biomarkers
HER2 amplificationHER2 overexpression
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