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Epidermal Growth Factor Receptor 2 Extracellular Domain 4
- Molecular classification
- Receptor Domain, Protein Domain
01
Overview
Epidermal Growth Factor Receptor 2 (HER2) Extracellular Domain 4 is a subdomain within the extracellular region of the HER2 receptor. It is involved in receptor dimerization and activation processes. HER2 overexpression, and in particular the accessibility and confirmation of the extracellular domains, is strongly implicated in various cancers, especially breast and gastric cancers, making this domain a target for therapeutic intervention. Monoclonal antibodies, such as trastuzumab, bind near domain IV, inhibiting dimerization/activation and flagging cells for immune-mediated destruction.
- Other names
- HER2 Extracellular Domain 4ErbB2 Extracellular Domain 4CD340 Extracellular Domain 4
02
Mechanism of action
Binding to the extracellular domain of HER2, inhibiting dimerization and downstream signaling
03
Biological functions
Protein-protein interactionReceptor dimerizationSignal transduction regulation
04
Disease associations
Cancer
05
Safety considerations
Cardiac toxicity (for anti-HER2 therapies)
06
Interacting drugs
07
Biomarkers
HER2 expression levels in tumors
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