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Target intelligence / Profile preview
ErbB Receptor (ErbB)
- Target
- ErbB
- Molecular classification
- Receptor Tyrosine Kinase, Receptor
01
Overview
The ErbB receptor family comprises four structurally related RTKs central to growth factor signaling, whose dysregulation drives many human cancers through aberrant activation of proliferation/survival/migration pathways. Their modular structure enables complex regulation via diverse ligands/dimers/adaptor protein interactions—making them prime targets for anti-cancer therapies.
- Other names
- Epidermal Growth Factor Receptor familyEGFR familyHER familyType I Receptor Tyrosine Kinases
02
Mechanism of action
Inhibition of receptor tyrosine kinase activity, blockade of ligand binding, prevention of dimerization, antibody-dependent cell-mediated cytotoxicity (ADCC)
03
Biological functions
Cell signalingCell proliferationCell survivalCell migrationCell differentiationApoptosis regulationOrganogenesisEpithelial homeostasisWound healing
04
Disease associations
CancerBreast cancerOvarian cancerNon-small cell lung cancerGliomaTumorigenesisMetastasis
05
Safety considerations
Drug resistanceCardiotoxicity (with some HER2 inhibitors)Skin rashDiarrheaInfusion reactionsDevelopment of other malignanciesInteractions with other medications
06
Interacting drugs
3 more in the full profile.
07
Biomarkers
EGFR expressionHER2 amplificationHER2 overexpressionEGFR mutationsERBB3 expression
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