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Target intelligence / Profile preview
ERBB2 receptor (HER2)
- Target
- HER2
- Molecular classification
- Receptor, Tyrosine Kinase Receptor, Epidermal Growth Factor Receptor family
01
Overview
ERBB2 (HER2) is a receptor tyrosine kinase and a member of the epidermal growth factor receptor (EGFR) family. It does not bind ligand directly but is activated through homo- or heterodimerization with other EGFR family members, leading to downstream signaling cascades that regulate cell proliferation, survival, differentiation, and migration. Overexpression or amplification of ERBB2 is associated with aggressive tumor behavior and poor prognosis in several cancers, particularly breast cancer, making it an important biomarker and therapeutic target.
- Other names
- ErbB-2NeuCD340
02
Mechanism of action
Inhibition of tyrosine kinase activity, antibody-dependent cell-mediated cytotoxicity (ADCC), receptor downregulation
03
Biological functions
Tyrosine-protein kinase activityCell proliferationCell survivalCell differentiationCell migrationCell growthCell divisionTissue homeostasisSignal transduction
04
Disease associations
Breast cancerOvarian cancerVisceral neuropathy familial type IIGlioma susceptibility syndromesCancer
05
Safety considerations
Resistance mechanisms to targeted therapiesCardiac dysfunction (for some HER2 inhibitors)Drug resistance
06
Interacting drugs
3 more in the full profile.
07
Biomarkers
HER2 overexpressionHER2 amplification
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