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Target intelligence / Profile preview
Human Leukocyte Antigen-E (None)
- Target
- None
- Molecular classification
- Non-classical MHC Class I molecule
01
Overview
HLA-E is a non-classical MHC class I molecule that plays a crucial role in immune regulation. It presents peptides, primarily derived from the leader sequences of other MHC class I molecules, to CD94/NKG2 receptors on NK cells and some CD8+ T lymphocytes. Binding to these receptors can either inhibit or activate NK cell responses, thereby balancing innate immunity with adaptive memory responses. Tumors can exploit high HLA-E expression to evade immune surveillance by inhibiting NK cell-mediated lysis.
- Other names
- HLA-EMHC class I antigen EHLA class I histocompatibility antigen, alpha chain E
02
Mechanism of action
N/A
03
Biological functions
Peptide presentationImmune regulationNK cell inhibitionNK cell activationT cell modulation
04
Disease associations
CancerImmune evasion
05
Safety considerations
Tumor immune evasionPotential for broad immune suppression
06
Biomarkers
HLA-E expression levelDisease-free survival (context-dependent)
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