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Target intelligence / Profile preview
Human Epidermal Growth Factor Receptor 2 Tyrosine Kinase (HER2)
- Target
- HER2
- Molecular classification
- Receptor, Receptor Tyrosine Kinase, EGFR/HER family
01
Overview
HER2 (ERBB2) is a transmembrane receptor tyrosine kinase that plays a critical role in cell proliferation, survival, differentiation, and migration. It is a member of the EGFR/HER family and is frequently overexpressed or amplified in various cancers, making it an important therapeutic target. HER2 activates downstream signaling pathways such as MAPK and PI3K-AKT upon dimerization.
- Other names
- ERBB2NeuCD340
02
Mechanism of action
Monoclonal antibodies, antibody-drug conjugates, small molecule inhibitors targeting kinase activity.
03
Biological functions
Cell proliferationCell survivalCell differentiationCell migrationSignal transduction
04
Disease associations
Cancer
05
Interacting drugs
06
Biomarkers
HER2 overexpressionHER2 gene amplification
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