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Target intelligence / Profile preview
Human Epidermal Growth Factor Receptor family (HER/ErbB family)
- Target
- HER/ErbB family
- Molecular classification
- Receptor, Tyrosine Kinase Receptor, Transmembrane receptor
01
Overview
The human epidermal growth factor receptor (HER/ErbB) family consists of four closely related transmembrane tyrosine kinase receptors: HER1 (EGFR/ErbB1), HER2 (ErbB2/neu), HER3 (ErbB3), and HER4 (ErbB4). Dimerization among these receptors—either as homodimers or heterodimers—is a critical event for their activation, leading to downstream signaling that regulates cell proliferation, survival, differentiation, and other processes relevant to cancer biology. Overexpression/amplification of these receptors—especially HER2—is implicated in various cancers and serves as a therapeutic target.
- Other names
- EGFR familyErbB receptor tyrosine kinase family
02
Mechanism of action
Tyrosine kinase inhibition, Receptor dimerization inhibition, Antibody-dependent cell-mediated cytotoxicity (ADCC)
03
Biological functions
Signal transductionCell proliferationCell survivalCell differentiationAngiogenesis
04
Disease associations
Cancer
05
Safety considerations
Resistance to targeted therapiesCardiotoxicity (with some HER2 inhibitors)Skin rash
06
Interacting drugs
2 more in the full profile.
07
Biomarkers
HER2 overexpression/amplificationEGFR expressionHER3 expression
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