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Target intelligence / Profile preview
Human Epidermal Growth Factor Receptor Type 2 (HER2)
- Target
- HER2
- Molecular classification
- Receptor, Receptor tyrosine kinase, ErbB receptor family
01
Overview
Human Epidermal Growth Factor Receptor Type 2 (HER2) is a receptor tyrosine kinase and a member of the ErbB family. Unlike other ErbB receptors, HER2 has no known natural ligand and is primarily activated through dimerization, particularly heterodimerization with HER3. Activation of HER2 triggers downstream signaling pathways such as MAPK and PI3K/Akt, promoting cell proliferation and survival. HER2 overexpression or amplification is observed in various cancers, making it a significant prognostic/predictive marker and a therapeutic target. Anti-HER2 therapies have improved outcomes in HER2-positive cancers.
- Other names
- ErbB2HER-2/neu
02
Mechanism of action
Targeted inhibition of HER2 signaling
03
Biological functions
Cell proliferationCell survivalAnti-apoptosisDifferentiationAngiogenesisInvasionMetastasisSignal transduction
04
Disease associations
CancerBreast cancerGastric cancerGastroesophageal cancerOvarian cancerEndometrial cancerBladder cancerLung cancerColon cancerHead and neck tumors
05
Safety considerations
Cardiac dysfunctionInfusion reactionsPulmonary toxicity
06
Interacting drugs
07
Biomarkers
HER2 overexpressionHER2 amplification
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