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Target intelligence / Profile preview
Human Epidermal Growth Factor Receptor Type IV (HER4)
- Target
- HER4
- Molecular classification
- Receptor, Tyrosine Kinase, EGFR/HER/ErbB Family
01
Overview
HER4 (Human Epidermal Growth Factor Receptor 4) is a receptor tyrosine kinase and a member of the EGFR/HER/ErbB family. It plays a critical role in various physiological functions, including cardiac development, central nervous system development, mammary gland differentiation, and regulation of gene transcription. It is activated by ligands such as neuregulins, betacellulin, epiregulin and HB-EGF, leading to dimerization and activation of downstream signaling pathways like MAPK/ERK and PI3K/Akt. Its role in cancer is complex and context-dependent, with studies suggesting both tumor-suppressive and pro-proliferative functions. Mutations and SNPs have been associated with schizophrenia and ALS. Disruption of HER2/HER4 signaling is implicated in cardiotoxicity.
- Other names
- ERBB4ALS19p180erbB4
02
Mechanism of action
Tyrosine kinase inhibition; modulation of dimerization
03
Biological functions
Signal transductionCell proliferationCell differentiationCell migrationApoptosisCardiac muscle differentiationMammary gland differentiationGene transcription
04
Disease associations
CancerBreast CancerSchizophreniaAmyotrophic Lateral Sclerosis
05
Safety considerations
Cardiotoxicity associated with anti-HER2 therapies disrupting HER2/HER4 signaling
06
Interacting drugs
1 more in the full profile.
07
Biomarkers
HER4 expression in estrogen receptor-positive breast cancer
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