Target intelligence / Profile preview

Human Papillomavirus Type 11 Major Capsid Protein L1 (L1)

Target: L1
Molecular classification: Structural protein, Capsid protein

Overview

The human papillomavirus type 11 major capsid protein L1 is a self-associating structural polypeptide essential for forming infectious virus particles. Its ability to form highly immunogenic virus-like particles makes it both central to natural infection processes and invaluable as an antigen in effective preventive vaccines against low-risk HPVs like type 11.

Mechanism of action

Vaccination with L1 VLPs induces neutralizing antibodies that prevent viral infection.

Biological functions

Viral capsid formationGenome protectionHost cell attachmentViral entryImmunogen

Disease associations

InfectionGenital wartsLaryngeal papillomatosis

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