Immune system and tissue repair pathways

Immune system and tissue repair pathways represent a complex network of biological processes involving various cell types, such as macrophages, T cells, and fibroblasts, that coordinate the body's response to injury and infection. These pathways are essential for maintaining homeostasis, as the immune system not only defends against pathogens but also orchestrates the clearance of debris and the regeneration of damaged tissues through the secretion of growth factors and cytokines (Gurtner et al., 2008; Eming et al., 2017). Dysregulation of these pathways can lead to chronic inflammatory conditions, autoimmune diseases, or pathological fibrosis, where the repair process becomes maladaptive (Wynn & Vannella, 2016). Because this term describes a broad set of physiological interactions rather than a single protein or receptor, it is not considered a discrete therapeutic target in the traditional pharmacological sense. Instead, drug development typically focuses on specific molecular components within these pathways, such as cytokine receptors or signaling kinases, to modulate the overall immune-repair balance (Karin & Clevers, 2016).

Other names

Immune-mediated tissue regenerationImmune-repair axisWound healing pathwaysInflammatory repair response

Modulation of specific molecular nodes, such as cytokines, growth factors, or intracellular signaling kinases, to shift the balance from chronic inflammation to functional tissue regeneration.