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Target intelligence / Profile preview
Inhibin beta E chain (Activin E)
- Target
- Activin E
- Molecular classification
- Growth factor, TGFβ superfamily, Activin
01
Overview
Activin E is a dimeric protein belonging to the TGFβ superfamily. It is composed of two βE subunits and signals through the ALK7 receptor to regulate adipose tissue function, energy metabolism, and inflammation. It influences genes involved in lipid and glucose metabolism, adipocyte hypertrophy, and immune response, making it a potential therapeutic target for metabolic disorders.
- Other names
- INHBEActivin beta-E subunit
02
Mechanism of action
Activin E signals through ALK7/ACVR1C, leading to SMAD2/3 phosphorylation and subsequent gene transcription regulation involved in metabolism and adipose tissue biology.
03
Biological functions
Adipose tissue regulationMetabolic regulationImmune response modulationEnergy homeostasis
04
Disease associations
Metabolic disordersObesityInflammationAdipose tissue dysfunction
05
Safety considerations
Potential for off-target effects due to TGFβ superfamily's broad influence on various cellular processes.Unclear long-term consequences of modulating activin E levels.Potential for disrupting metabolic homeostasis if not precisely targeted.
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