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Target intelligence / Profile preview
Interleukin 13 Receptor Alpha 1 (IL13RA1)
- Target
- IL13RA1
- Molecular classification
- Receptor, Type I transmembrane protein, Cytokine receptor
01
Overview
Interleukin 13 Receptor Alpha 1 (IL13RA1) is a subunit of the interleukin-13 receptor complex. It plays a key role in mediating immune responses, particularly those involving the cytokines interleukin-4 (IL-4) and interleukin-13 (IL-13). It forms functional heterodimeric receptors with the interleukin-4 receptor alpha chain (IL-4Rα). This complex can bind both IL-4 and IL-13, triggering downstream signaling pathways, notably the JAK/STAT pathway. IL-13RA1 is expressed ubiquitously across tissues and is implicated in diseases such as asthma, autoimmune disorders, and cancer.
- Other names
- CD213A1IL-13RaNR4CT19Interleukin 13 receptor subunit alpha 1
02
Mechanism of action
Monoclonal antibodies (e.g., Dupilumab) block IL-4 and IL-13 signaling by targeting shared receptor subunits.
03
Biological functions
Signal transductionImmune responseRegulation of B cell expansionMediating IL-4 and IL-13 signaling
04
Disease associations
AsthmaAutoimmunity (e.g., lupus)Cancer
05
Safety considerations
Altered expression linked variably either with tumor progression or suppression depending on context. High expression correlates with better survival rates among lung cancer patients but poorer outcomes elsewhere.
06
Interacting drugs
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