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Target intelligence / Profile preview
Interleukin 4 (IL-4)
- Target
- IL-4
- Molecular classification
- Cytokine, Interleukin, Signaling molecule
01
Overview
Interleukin 4 (IL-4) is a cytokine that plays a central role in regulating humoral and adaptive immunity. It is primarily secreted by mast cells, Th2 cells, eosinophils, and basophils. IL-4 is crucial for Th2 cell differentiation and promotes IgE production, leading to allergic inflammation. Targeting IL-4 or its receptor is a therapeutic strategy for treating allergic diseases.
- Other names
- IL4B cell stimulatory factor-1BSF-1Lymphocyte stimulatory factor 1LSF-1
02
Mechanism of action
IL-4 inhibitors block the binding of IL-4 to its receptor, preventing downstream signaling and reducing the inflammatory response. Some therapies target the receptor itself.
03
Biological functions
B cell proliferationT cell proliferationIgE class switchingMHC class II upregulationTh2 differentiationHumoral immunity regulationAlternative macrophage activation
04
Disease associations
AsthmaEczemaHay feverAtopic dermatitisAllergic inflammationFibrosis
05
Safety considerations
Potential for immunosuppressionRisk of infections
06
Interacting drugs
1 more in the full profile.
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