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Target intelligence / Profile preview
Tyrosine-protein kinase JAK3 (JAK3)
- Target
- JAK3
- Molecular classification
- Enzyme, Tyrosine Kinase, Protein Kinase, Non-receptor tyrosine kinase
01
Overview
Tyrosine-protein kinase JAK3 (Janus kinase 3, JAK-3) is a non-receptor tyrosine kinase primarily involved in signal transduction for cytokine receptors that share the common gamma chain (γc), such as those for interleukins IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. It plays a crucial role in hematopoiesis—especially T-cell development—and mediates essential signaling events in both innate and adaptive immunity. Mutations can lead to SCID or leukemia. Selective inhibitors targeting Cys909 are used therapeutically.
- Other names
- Janus kinase 3JAK-3Leukocyte janus kinaseL-JAK
02
Mechanism of action
JAK3 inhibition
03
Biological functions
Signal transductionImmune responseCell proliferationHematopoiesisCytokine receptor signaling
04
Disease associations
Severe Combined Immunodeficiency (SCID)LeukemiaCancerAutoimmune diseasesRheumatoid Arthritis
05
Safety considerations
ImmunosuppressionIncreased risk of infectionPotential for off-target effects
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