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Large Neutral Amino Acid Transporter 1 (LAT1)
- Target
- LAT1
- Molecular classification
- Transporter, Solute Carrier Family 7 (SLC7), Amino Acid Transporter, APC (amino acid-polyamine-organo cation) superfamily
01
Overview
LAT1 (SLC7A5) is a light subunit of a heterodimeric amino acid transporter that forms a complex with CD98/4F2hc (SLC3A2). This complex facilitates the transport of large neutral amino acids across cell membranes, particularly at the blood-brain barrier, placenta, and in cancer cells. It plays a crucial role in nutrient uptake, cell growth regulation via mTORC1 signaling, and is implicated in various diseases including cancer and neurological disorders. LAT1 is a target for drug delivery and cancer therapy.
- Other names
- SLC7A5Large neutral amino acid transporter small subunit 5
02
Mechanism of action
Na⁺-, pH-independent antiport/exchange of large neutral amino acids
03
Biological functions
Amino acid transportNutrient uptakemTORC1 signaling regulationCell growth regulation
04
Disease associations
CancerNeurological disordersDiabetesImmunological conditions
05
Safety considerations
Selectivity challenges due to overlapping substrate specificity with other transporters (e.g., LAT2)
06
Interacting drugs
L-DOPA
2 more in the full profile.
07
Biomarkers
LAT1 expression levels in tumors
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