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Target intelligence / Profile preview
Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b (CD32B)
- Target
- CD32B
- Molecular classification
- Receptor, Immunoglobulin superfamily, Type I integral membrane glycoprotein
01
Overview
CD32B (FcγRIIb) is a low-affinity receptor for the Fc region of IgG. It functions as a negative regulator of immune responses by inhibiting cell activation, proliferation, endocytosis, phagocytosis, and degranulation. It is expressed on B cells, monocytes, macrophages, granulocytes, platelets, and mast cells. Engagement of CD32B with immune complexes leads to phosphorylation of its ITIM motif, which recruits phosphatases to counteract activating signals. Due to its role in down-modulating immune responses, CD32B is a target for research into autoimmune diseases and therapeutic antibody design.
- Other names
- CD32BCD32b/cFc gamma R2Fc gamma R2bFc gamma RIIFc gamma RIIbFcg R2Fcg R2bFcg RIIFcg RIIbFCGR2FCGR2BFcgr2b/cFCGRIIFCGRIIBFCR2FCR2BIGFR2B
02
Mechanism of action
Phosphorylation of ITIM motif recruits SH2-domain-containing phosphatases to counteract activating signals from ITAM-bearing receptors.
03
Biological functions
Negative regulation of cell activationDown-modulation of cell activationInhibition of proliferationInhibition of endocytosisInhibition of phagocytosisInhibition of degranulationModulation of antibody productionRegulation/clearance of immune complexesInvolvement in apoptotic signaling pathwaysRegulation of innate immune responsesResponse to bacteria
04
Disease associations
Autoimmune diseasesInflammation
05
Safety considerations
Sequence similarity between subtypes makes it challenging to distinguish between them using antibodies.
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