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Target intelligence / Profile preview
Melatonin Receptor Type 1B (MT2)
- Target
- MT2
- Molecular classification
- G-protein coupled receptor, GPCR, Class A GPCR, Receptor
01
Overview
MT2, also known as Melatonin receptor type 1B or MTNR1B, is one of two high-affinity G protein-coupled receptors (GPCRs) for melatonin. It plays a central role in phase-shifting the internal circadian clock, selectively increases non–rapid eye movement (NREM) sleep, influences light-dependent retinal functions, and regulates bone metabolism. Dysfunction or altered expression/activity of MT2 has been linked with sleep disorders, circadian rhythm abnormalities, mood disorders, pain modulation, and type 2 diabetes pathogenesis.
- Other names
- MEL-1B-RMelatonin receptor 1BMelatonin receptor MEL1BMt2rFGQTL2Mel1b receptorMtNR1b
02
Mechanism of action
Gi-mediated inhibition of cAMP/cGMP; PKC activation
03
Biological functions
Circadian rhythm entrainmentNREM sleep promotionRetinal signalingSignal transduction
04
Disease associations
Sleep disordersCircadian rhythm abnormalitiesMood disordersAnxietyDepressionPain modulationType 2 diabetes
05
Interacting drugs
Melatonin
1 more in the full profile.
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