MicroRNA 889 (miR-889)

MicroRNA 889 (miR-889) is a small, non-coding RNA molecule that regulates gene expression at the post-transcriptional level by binding to complementary sequences on target messenger RNAs, leading to their degradation or translational repression. miR-889 is implicated in the regulation of cellular processes such as proliferation, migration, invasion, autophagy, and epithelial–mesenchymal transition. The role of miR-889 is context-dependent: it can act as an oncogene (by promoting cancer progression in hepatocellular carcinoma and retinoblastoma) or as a tumor suppressor (in non-small cell lung cancer). Additionally, miR-889 is involved in infectious disease, particularly latent tuberculosis infection, where it maintains mycobacterial survival by inhibiting autophagy through suppression of TWEAK expression. miR-889 expression levels may serve as a prognostic biomarker in cancer and as a marker for latent tuberculosis infection and reactivation. No direct small-molecule drugs target miR-889, but its expression may be affected indirectly by biologics such as adalimumab, which modulates TNF-α levels and thus impacts miR-889.

Other names

hsa-mir-889MIRN889mir-889MIR889miR-889-3p

Post-transcriptional gene silencing by mRNA degradation or translation inhibition via RISC complex Targeting specific mRNAs (e.g., KLF9, DAB2IP, TAB1, BMPR2, TWEAK)