Molecular targets in skin barrier function and inflammation pathways

The term "Molecular targets in skin barrier function and inflammation pathways" refers to a diverse group of proteins and signaling cascades that maintain skin integrity and regulate immune homeostasis. The skin barrier is primarily composed of the stratum corneum, where structural proteins like filaggrin and loricrin, along with intercellular lipids, provide a physical defense against environmental stressors [1]. Inflammation pathways in the skin are often triggered by barrier disruption, leading to the activation of the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway and the release of pro-inflammatory cytokines such as IL-4, IL-13, and IL-17 [2]. Dysregulation of these molecular targets is a hallmark of inflammatory dermatoses, including atopic dermatitis and psoriasis, where a compromised barrier facilitates allergen penetration and chronic inflammation [3]. Therapeutic interventions in this field are highly varied, ranging from topical agents that enhance barrier repair to systemic biologics and small molecules that specifically inhibit inflammatory mediators [4]. Because this entry describes a broad physiological system and multiple distinct molecular entities rather than a single protein or receptor, it is classified as a pathway or therapeutic area rather than a discrete therapeutic target.

Other names

Skin barrier and inflammation signalingEpidermal barrier pathwaysCutaneous inflammatory cascades

This category involves multiple mechanisms including inhibition of Janus kinases (JAKs), neutralization of Th2/Th17 cytokines, and modulation of phosphodiesterase-4 (PDE4) to restore barrier integrity and suppress inflammation.