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Target intelligence / Profile preview
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma (PI3Kγ)
- Target
- PI3Kγ
- Molecular classification
- Enzyme, Class I PI3K, Class IB Phosphoinositide-specific kinase
01
Overview
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma (PI3Kγ or p110γ) is a lipid kinase belonging to the class I PI3K family. It functions as a heterodimer with regulatory subunits p101 or p87/p84, playing critical roles in immune cell signaling, cardiovascular function, and other cellular processes through PIP3 production and scaffolding functions. PI3Kγ is activated downstream of GPCRs and regulates the Akt/mTOR pathway.
- Other names
- p110γPIK3CG
02
Mechanism of action
Inhibition of PI3Kγ kinase activity
03
Biological functions
Lipid kinase activitySignal transductionImmune responseCell growthCell survivalCell proliferationCell differentiationScaffoldingRegulation of cAMP levels
04
Disease associations
Inflammatory diseasesCardiovascular disordersCancerHeart failure
05
Interacting drugs
AZD3458
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