Proinflammatory cytokines – indirect pathway-level modulation

Proinflammatory cytokines – indirect pathway-level modulation is a therapeutic strategy focused on regulating the intracellular signaling networks that govern the production and activity of multiple inflammatory mediators (NCBI, 2017: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542673/). Rather than targeting a single cytokine like TNF-alpha or IL-6 with a}

Other names

Indirect cytokine modulationCytokine signaling pathway inhibitionUpstream inflammatory signaling modulationIntracellular cytokine pathway modulation

Inhibition of intracellular signaling nodes such as Janus kinases (JAKs), the IKK complex, or phosphodiesterases, and the modulation of transcription factors like NF-kappaB or the glucocorticoid receptor to suppress the transcription and translation of multiple proinflammatory cytokine genes.