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Target intelligence / Profile preview
Receptor Tyrosine-Protein Kinase erbB2 (HER2)
- Target
- HER2
- Molecular classification
- Receptor Tyrosine Kinase, Protein Kinase, EGF receptor subfamily
01
Overview
Receptor Tyrosine-Protein Kinase erbB2 (HER2) is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family and a receptor tyrosine kinase. Unlike other EGFR family members, HER2 does not directly bind ligands but is activated by homo- or heterodimerization with other ERBB receptors, leading to autophosphorylation and activation of downstream signaling pathways such as MAPK and PI3K. HER2 plays key roles in cell growth, differentiation, and survival. Overexpression or amplification of HER2 is observed in a significant percentage of breast and gastric cancers, driving aggressive tumor behavior and serving as a crucial biomarker for targeted therapies like trastuzumab and lapatinib.
- Other names
- ErbB2CD340NeuERBB2
02
Mechanism of action
Inhibition of HER2 tyrosine kinase activity, antibody-dependent cell-mediated cytotoxicity, and/or receptor dimerization blockade.
03
Biological functions
Cell growth regulationCell differentiationSignal transductionMicrotubule outgrowth/stabilizationTranscriptional regulation
04
Disease associations
Breast cancerGastric cancerGastroesophageal cancerFamilial visceral neuropathy type 2Glioma susceptibility
05
Safety considerations
Cardiac dysfunctionInfusion reactions
06
Interacting drugs
2 more in the full profile.
07
Biomarkers
ERBB2/HER2 overexpression/amplification
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