Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Thymic Stromal Lymphopoietin (None)
- Target
- None
- Molecular classification
- Cytokine
01
Overview
Thymic stromal lymphopoietin (TSLP) is a cytokine primarily produced by epithelial cells. It plays a crucial role in initiating and promoting type 2 helper T cell (Th2)-mediated inflammation in allergic diseases like atopic dermatitis and asthma. TSLP exists in two main isoforms, a long form (lfTSLP) upregulated during inflammation and a short form (sfTSLP) involved in tissue homeostasis. Drugs targeting TSLP, like tezepelumab, aim to neutralize the cytokine and reduce inflammation.
- Other names
- TSLP
02
Mechanism of action
Neutralizes TSLP, preventing its interaction with the TSLP receptor complex.
03
Biological functions
Immune modulationTh2 polarizationB cell activationT cell activationMast cell activationEpithelial homeostasis
04
Disease associations
Atopic dermatitisAsthmaAllergic rhinitisAllergic esophagitisInflammatory bowel diseaseObesityMetabolic syndromeCancer
05
Safety considerations
Potential disruption of homeostatic functions of sfTSLPRisk of immunosuppression
06
Interacting drugs
07
Biomarkers
TSLP expression levels in affected tissues (e.g., skin, lung)
Beyond the preview
Go deeper on Thymic Stromal Lymphopoietin (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Thymic Stromal Lymphopoietin (None).