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Target intelligence / Profile preview
Nuclear Factor Kappa B Subunit p65 (RELA)
- Target
- RELA
- Molecular classification
- Transcription factor
01
Overview
Nuclear factor kappa B subunit p65 (RELA) is a key component of the NF-κB transcription factor family, playing a central role in regulating immune responses, inflammation, cell survival, and tumorigenesis. It forms heterodimers with other NF-κB subunits, primarily p50, and translocates to the nucleus upon activation to regulate target gene expression. Aberrant activation of p65/NF-κB is implicated in chronic inflammatory diseases and cancer.
- Other names
- Transcription factor p65NFKB3
02
Mechanism of action
Inhibition of NF-κB signaling pathway via disruption of p65 DNA binding or transcriptional activity.
03
Biological functions
Regulation of immune responsesInflammationCell survivalApoptosisCell proliferationCell differentiationTranscriptional regulation
04
Disease associations
Chronic inflammationAutoimmune disordersCancer
05
Safety considerations
Potential for broad immunosuppressionOff-target effects on other signaling pathways
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