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Target intelligence / Profile preview
Tumor-associated membrane antigen (TAMA)
- Target
- TAMA
- Molecular classification
- Protein, Glycoprotein, Cell-surface antigen
01
Overview
Tumor-associated membrane antigens (TAMAs) are cell-surface proteins or glycoproteins that are upregulated or aberrantly expressed on cancer cells. They serve as targets for immune surveillance and therapeutic intervention. TAMAs can be used as diagnostic markers and targeted by monoclonal antibodies, antibody-drug conjugates (ADCs), and CAR-T cell therapy. However, immune tolerance and suppression within the tumor microenvironment can limit the efficacy of TAMA-targeted therapies.
- Other names
- Tumor associated membrane antigenTAA (Tumor-associated antigen, membrane-bound)
02
Mechanism of action
Antibody-dependent cellular cytotoxicity (ADCC), complement activation, phagocytosis enhancement, direct interference with essential signaling pathways required for tumor growth/survival
03
Biological functions
Cell adhesionSignal transductionGrowth regulationMetabolismImmune response
04
Disease associations
Cancer
05
Safety considerations
Immune toleranceSuppression within the tumor microenvironmentOn-target, off-tumor toxicity
06
Interacting drugs
3 more in the full profile.
07
Biomarkers
HER2/neuPSMATROP2Nectin-4Folate Receptor AlphaTissue Factor
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