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Target intelligence / Profile preview
Tumour Necrosis Factor (TNF)
- Target
- TNF
- Molecular classification
- Cytokine, Tumor Necrosis Factor Superfamily, Pro-inflammatory cytokine
01
Overview
Tumour necrosis factor (TNF), formerly known as TNF-α, is a pro-inflammatory cytokine and a key chemical messenger produced by the immune system. It plays a central role in mediating inflammation and orchestrates various physiological and pathological processes, including immune cell activation, fever induction, apoptosis (programmed cell death), necroptosis (regulated necrosis), and tissue homeostasis. Excessive or dysregulated production of TNF is implicated in several diseases, including chronic inflammatory diseases like rheumatoid arthritis, psoriasis, and inflammatory bowel disease, as well as cancer and neurodegenerative disorders. Therapeutics targeting TNF are widely used to treat autoimmune/inflammatory disorders by blocking its interaction with receptors.
- Other names
- TNF-αCachectin
02
Mechanism of action
Monoclonal antibodies or soluble receptor constructs blocking TNF interaction with receptors
03
Biological functions
Inflammation inductionApoptosis regulationNecroptosis regulationImmunity modulationImmune cell activationFever inductionTissue homeostasisCytokine secretion regulationRegulation of white blood cell activityRegulation of blood coagulationTissue regeneration
04
Disease associations
Chronic inflammatory diseasesRheumatoid arthritisPsoriasisInflammatory bowel diseaseCancerLiver fibrosisNeurodegenerative disordersAlzheimer's disease
05
Safety considerations
Increased risk of infectionReactivation of latent tuberculosisIncreased risk of certain cancers
06
Interacting drugs
4 more in the full profile.
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