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Target intelligence / Profile preview
Vesicular Stomatitis Virus-Mediated Oncolysis (VSV Oncolysis)
- Target
- VSV Oncolysis
- Molecular classification
- Virus, Oncolytic virus
01
Overview
Vesicular stomatitis virus (VSV)-mediated oncolysis is a cancer therapy approach that utilizes VSV, an RNA virus, to selectively infect and destroy cancer cells. The virus exploits defects in the type I interferon (IFN) signaling pathway, which are common in tumors, allowing preferential replication in malignant cells while sparing normal tissue. The oncolytic mechanism involves direct cell lysis, vascular shutdown, and immune stimulation. Engineering strategies focus on enhancing safety, selectivity, and immunogenicity. Resistance can occur due to intact IFN responses or poor viral attachment, and may be overcome by combination therapies.
- Other names
- VSV-mediated oncolysisVSV oncolytic virotherapyOncolytic VSV
02
Mechanism of action
Selective infection and lysis of cancer cells due to defective type I interferon response; vascular shutdown; cytokine induction.
03
Biological functions
Viral replicationCell lysisImmune stimulation (conditional)Antitumor activity
04
Disease associations
Cancer therapy
05
Safety considerations
Neurotoxicity (addressed by attenuation)Off-target infection of normal cells (minimized by selectivity)Potential for immune suppressionPre-existing immunity (though low seroprevalence)
06
Interacting drugs
07
Biomarkers
Type I IFN pathway status in tumor cellsViral load in tumorAnti-VSV antibody titers
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