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Voltage-dependent T-type calcium channel subunit alpha-1H
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
The voltage-dependent T-type calcium channel subunit alpha-1H (Ca_v3.2) is a pore-forming subunit of T-type calcium channels. These channels are activated by small depolarizations and mediate Ca^2+ influx, playing crucial roles in neuronal excitability, cardiac pacemaking, and endocrine function. Mutations in CACNA1H are linked to epilepsy and autism spectrum disorder.
- Other names
- CACNA1HCa_v3.2T-type calcium channel alpha 1H subunit
02
Mechanism of action
T-type calcium channel blockers reduce neuronal excitability by inhibiting Ca^2+ influx through the Ca_v3.2 channel.
03
Biological functions
Calcium ion transmembrane transportRegulation of neuronal excitabilityPacemaking activitySynaptic transmissionAldosterone production signaling pathway
04
Disease associations
EpilepsyChildhood Absence Epilepsy (CAE)Idiopathic Generalized Epilepsy (IGE)Autism Spectrum DisorderCardiovascular disease
05
Interacting drugs
Nickel ions
2 more in the full profile.
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