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Target intelligence / Profile preview
Solute Carrier Family 39 Member 6 (SLC39A6)
- Target
- SLC39A6
- Molecular classification
- Transporter, Solute Carrier Family 39, ZIP family, LIV-1 subfamily
01
Overview
SLC39A6 encodes the zinc-influx transporter protein LIV-1/ZIP6, a member of the ZIP family. It plays a critical role in maintaining cellular zinc homeostasis by transporting zinc into cells. Overexpression is observed in several cancers, including breast cancer (especially estrogen receptor-positive), prostate cancer, kidney tumors, and esophageal squamous cell carcinoma (ESCC), making it a potential therapeutic target and diagnostic marker.
- Other names
- LIV-1ZIP6Zinc transporter ZIP6LIV1
02
Biological functions
Zinc influxZinc homeostasisRegulation of autophagyCell growth/death balanceCell migrationCell invasionT-cell activationEpithelial-to-mesenchymal transition (EMT)
03
Disease associations
CancerBreast cancer (ER+)Prostate cancerKidney tumorsEsophageal squamous cell carcinoma (ESCC)
04
Biomarkers
Estrogen receptor-positive breast cancerLuminal A breast cancer subtypeESCC patient survival
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