Trial intelligence / Profile preview

BIS-Program neoadjuvant immunotherapy in early-stage breast cancer

2024-512826-26-00Phase 2Completed

Sponsor
Gustave Roussy
Start
Sep 2024
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes
Countries
1
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Overview

Phase 2, randomised, open-label trial of atezolizumab, bevacizumab, pertuzumab and trastuzumab in triple-negative breast cancer (TNBC) and breast cancer (2 arms), sponsored by Gustave Roussy. Primary endpoint: Two-fold increase in GzmB+ CD8+ T cell levels from baseline to post-treatment window in biopsies. Started Sep 2024; status: completed.

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Drugs

atezolizumabbevacizumabpertuzumabtrastuzumab
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Conditions

triple-negative breast cancer (TNBC)breast cancer

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