Trial intelligence / Profile preview

DESTINY-Gastric05 first-line HER2-positive gastric/GEJ cancer trial

2024-513122-27-00Phase 3Authorised

Sponsor
Daiichi Sankyo Co., Ltd.
Start
Jun 2025
Modality
Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
Countries
26
01

Overview

Phase 3, randomised, open-label trial of trastuzumab deruxtecan, trastuzumab, pembrolizumab, capecitabine, fluorouracil and 2 more in gastric adenocarcinoma and gastroesophageal junction adenocarcinoma (2 arms), sponsored by Daiichi Sankyo Co., Ltd. Primary endpoint: Progression-free survival. Planned start Jun 2025; status: authorised.

02

Drugs

trastuzumab deruxtecantrastuzumabpembrolizumabcapecitabinefluorouracil
03

Conditions

gastric adenocarcinomagastroesophageal junction adenocarcinoma

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