Trial intelligence / Profile preview

ALL-TARGET trial in relapsed or refractory T-cell acute lymphoblastic leukemia

2024-516570-30-00Phase 2Authorised

Sponsor
Centre Hospitalier de Versailles
Start
May 2026
Modality
Small Molecules, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Countries
5
01

Overview

Phase 2, randomised, open-label trial in t-cell acute lymphoblastic leukemia (T-ALL) comparing TTO1: venetoclax + tofacitinib, TTO2: venetoclax + everolimus + recombinant L-asparaginase and TTO3: venetoclax + azacitidine (3 arms). Primary endpoint: Hematological remission rate. Planned start May 2026; status: authorised.

02

Drugs

venetoclaxtofacitinibeverolimusazacitidine
03

Conditions

t-cell acute lymphoblastic leukemia (T-ALL)

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