Trial intelligence / Profile preview

TOP-RA trial

2025-524593-42-00Phase 4Authorised

Sponsor
Leiden University
Start
Oct 2026
Modality
Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Monoclonal Antibodies → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes
Countries
1
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Overview

Phase 4, randomised, open-label trial of abatacept, adalimumab, certolizumab pegol, etanercept, infliximab and 2 more in rheumatoid arthritis (RA) (3 arms), sponsored by Leiden University. Primary endpoint: Successful tapering probability at 9 months. Planned start Oct 2026; status: authorised.

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Drugs

abataceptadalimumabcertolizumab pegoletanerceptinfliximab
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Conditions

rheumatoid arthritis (RA)

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