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TRAIN-5: neoadjuvant trastuzumab, pertuzumab, and zongertinib without chemotherapy in HER2-positive breast cancer

2026-526214-93-00Phase 2Authorised

Sponsor
Netherlands Cancer Institute
Start
Oct 2026
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Countries
1
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Overview

Phase 2, open-label, single-arm trial of zongertinib, trastuzumab and pertuzumab in breast cancer, sponsored by Netherlands Cancer Institute. Primary endpoint: Incidence and severity of adverse events. Planned start Oct 2026; status: authorised.

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Drugs

zongertinibtrastuzumabpertuzumab
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Conditions

breast cancer

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