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Adult HLH clinical study of dexamethasone, tofacitinib, etoposide, decitabine, and salvage chemotherapy
ChiCTR2200063435Phase 4Not yet recruiting
- Sponsor
- Union Hospital
- Start
- Jul 2022
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules
- Countries
- 1
01
Overview
Phase 4, open-label trial of tofacitinib, dexamethasone, etoposide, decitabine, gemcitabine and 2 more in haemophagocytic lymphohistiocytosis (HLH) (4 arms), sponsored by Union Hospital. Primary endpoints: Overall response rate at end of induction therapy, Overall response rate at end of maintenance therapy and 1 more. Planned start Jul 2022; status: not yet recruiting.
02
Drugs
03
Conditions
haemophagocytic lymphohistiocytosis (HLH)
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