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Modafinil and Citalopram for Cocaine Dependence in Methadone-Maintained Patients
NCT00218036Phase 2
Key facts
- Status
- Terminated
- Start
- Jul 2006
- Primary completion
- Feb 2010
- Countries
- 1
- Sponsor
- UTHealth Houston
- Modality
- Small Molecules
- Drugs
- modafinilcitalopram
- Conditions
- cocaine dependence
01
Overview
Phase 2, randomised, double-blind trial of modafinil and citalopram in cocaine dependence (5 arms), sponsored by UTHealth Houston. Primary endpoint: Confirmed Abstinence From Cocaine at 12 weeks. Started Jul 2006; status: terminated.
02
Design
5 arms- Study design
- RandomizedDouble-blind
Modafinil 200mg
Modafinil 200mg + Methadone
Modafinil 400mg
Modafinil 400mg + Methadone
Citalopram 20mg
Citalopram 20mg + Methadone
Citalopram 40mg
Citalopram 40mg + Methadone
Placebo
Placebo + Methadone
03
Who it enrols
Inclusion: Cocaine abuse and dependence, Opiate dependence, Good general physical and psychiatric health. Exclusion: Other psychiatric disorders, Current cardiovascular disease, Probation or parole constraints.
04
Endpoints
Primary
Confirmed Abstinence From Cocaine
Secondary
Retention
Medication Compliance
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