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Epidural Clonidine for Postoperative Pain and Hyperalgesia
NCT00417443Phase 3
Key facts
- Status
- Withdrawn
- Start
- Dec 2007
- Countries
- 1
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
- Modality
- Small Molecules
- Drugs
- clonidine
- Conditions
- postoperative painPostoperative hyperalgesiachronic pain
01
Overview
Phase 3, randomised trial of clonidine in postoperative pain, Postoperative hyperalgesia and chronic pain, sponsored by Cambridge University Hospitals NHS Foundation Trust. Planned start Dec 2007; status: withdrawn.
02
Design
- Study design
- Randomized
03
Who it enrols
Patients aged 18-80 scheduled for elective major bowel surgery via vertical midline incision requiring an epidural catheter.
04
Registry description
We propose performing a study in which we compare the effects of bupivacaine and fentanyl with a different drug combination - bupivacaine and clonidine. The principal research questions of the study are:
1. To compare the effect of clonidine (with bupivacaine), injected into the epidural space on the extent of hyperalgesia (abnormal pain/sensitivity in the uninjured skin surrounding the operation site) in patients undergoing operations for bowel disease, with that of fentanyl (with bupivacaine). 2. To compare the effect of clonidine (with bupivacaine), injected into the epidural space on…
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