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Efficacy of Diacerein in Knee Osteoarthritis
NCT00445276Phase 4
Key facts
- Status
- Completed
- Start
- Nov 2005
- Primary completion
- Sep 2006
- Countries
- 1
- Sponsor
- Negma Group
- Modality
- DNA Intercalators/Alkylators
- Drugs
- diacerein
- Conditions
- knee osteoarthritis (OA)
01
Overview
Phase 4, randomised, double-blind trial of diacerein in knee osteoarthritis (OA) (2 arms), sponsored by Negma Group. Primary endpoints: Visual Analog Scale on pain movement and Western Ontario and McMaster Universities Osteoarthritis Index Section A 1.1. Started Nov 2005; status: completed.
02
Design
2 arms- Study design
- RandomizedDouble-blind
Diacerein
Diacerein treatment
Control
Placebo or Active Control
03
Endpoints
Primary
Visual Analog Scale on pain movement
Western Ontario and McMaster Universities Osteoarthritis Index Section A 1.1
Secondary
Western Ontario and McMaster Universities Osteoarthritis Index Total Score
Western Ontario and McMaster Universities Osteoarthritis Index Pain Subscale
Western Ontario and McMaster Universities Osteoarthritis Index Physical Function Subscale
Paracetamol consumption
Global assessment of the patient
Responder patients with OMERACT-OARSI criteria
Tolerance
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