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Magnesium Sulphate and Sugammadex in Gynecological Surgery
NCT01972659Phase 4
Key facts
- Status
- Completed
- Start
- Oct 2012
- Primary completion
- Dec 2013
- Countries
- 1
- Sponsor
- Kocaeli University
- Modality
- Small Molecules
- Drugs
- magnesium sulfate
- Conditions
- neuromuscular blockade (NMB)
01
Overview
Phase 4, randomised, double-blind trial of magnesium sulfate in neuromuscular blockade (NMB), sponsored by Kocaeli University. Started Oct 2012; status: completed.
02
Design
- Study design
- RandomizedDouble-blind
03
Who it enrols
Female patients aged 18-60, ASA I-II, undergoing elective gynecological surgery requiring intubation, excluding those with high BMI, GERD, or neuromuscular/organ insufficiency.
04
Registry description
Background: The aim of this prospective study was to evaluate the effect of magnesium on the reversal of rocuronium-induced neuromuscular block by sugammadex.
Methods: Eighty patients, aged 18 to 60 years, American Society of Anesthesiologists I-II, undergoing elective gynecological surgery were enrolled. Anaesthesia was induced with propofol and fentanyl and was maintained with 60% nitrous oxide and Oxygen in sevoflurane. The magnesium group received 50 milligram/kilogram (mg/kg) Magnesium intravenous (iv) as a bolus and 15 mg/kg/hour by continuous infusion until the completion of surgery.…
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