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Gut Microbiota and Nutrient Absorption Study
NCT02037295Phase 2
Key facts
- Status
- Completed
- Start
- Jan 2014
- Primary completion
- Mar 2019
- Countries
- 1
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases
- Modality
- Cyclic Peptides, Antimicrobial Peptides, Small Molecules
- Drugs
- vancomycin
- Conditions
- obesity
01
Overview
Phase 2, randomised, double-blind trial of vancomycin in obesity, sponsored by National Institute of Diabetes and Digestive and Kidney Diseases. Started Jan 2014; status: completed.
02
Design
- Study design
- RandomizedDouble-blind
03
Registry description
We propose to study both stool and urine energy loss in 24 individuals on two experimental diets (50% increased and 50% reduced nutrient load relative to body size) in a random cross-over design. Following this over/underfeeding, volunteers will also be randomly assigned to a placebo versus oral antibiotic medication arm. This study will extend our previous findings by investigating whether 1) nutrient absorption changes upon similar increases/decreases in relative nutrient load and 2) whether manipulation of gut microbial communities with antibiotics alters nutrient absorption and 3) how…
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