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Fluoride/Arginine Toothpaste Remineralization Study
NCT02388178Phase 2
Key facts
- Status
- Withdrawn
- Start
- Apr 2015
- Primary completion
- Jul 2015
- Sponsor
- Colgate-Palmolive
- Modality
- Peptides, Recombinant Proteins and Enzymes, Small Molecules
- Drugs
- arginine
- Conditions
- dental caries
01
Overview
Phase 2, randomised, double-blind trial of arginine in dental caries (3 arms), sponsored by Colgate-Palmolive. Primary endpoint: Mineral Change (delta Z) at 2 weeks. Planned start Apr 2015; status: withdrawn.
02
Design
3 arms- Study design
- RandomizedDouble-blind
Placebo
Fluoride-free toothpaste
Arginine + Fluoride
Experimental toothpaste
Fluoride
Active control
03
Who it enrols
Adults 18-50 with at least 20 natural teeth and normal salivary flow, excluding those with periodontal disease, tobacco use, or recent antibiotic use.
04
Endpoints
Primary
Mineral Change (delta Z)
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